The film was shot during the Rhinestone Cowboy's 2012 Goodbye Tour, which took place after he had been diagnosed with Alzheimer's disease. Filmed over 425 days and 151 shows, Campbell's tour manager Bill Macclay admits that he wasn't sure who would come to Campbell's final shows. "Part of me was afraid that I thought people were going to the show because they were going to see it crash," Maclay said in the film's trailer.

The film follows the singer as he learns from his doctor in June of 2011 that he has Alzheimer's disease. When interviewed about it, Campbell asserted, "I ain't done yet, tell them that."

Glen Campbell: I'll Be Me includes interviews with the Edge, Bruce Springsteen, Chad Smith of Red Hot Chili Peppers, Blake Shelton, Sheryl Crow, Keith Urban, Brad Paisley, Taylor Swift, Vince Gill, Steve Martin, Bill Clinton, Paul McCartney, Jimmy Webb and Jay Leno.