The legendary boxer declared the three mid-2000s titans irrelevant, which didn't fly with 50 Cent. Never one to let a slight go unchecked, 50 took the beef to Instagram.

50 stares at the camera in disbelief: "I woke up. Looked at the computer. The computer say Floyd say "F**k T.I., f**k Nelly. F**k 50. I'm like, 'What he say f**k me for? Nelly f**ked your first baby mama Melissa. Then took your f**king fiance. Say f**k that, n***a."

50 continues to clap back with a second video set in his expansive backyard, in which he challenges Mayweather to a special edition of the Ice Bucket Challenge.