The robotic, retro-futuristic genre known as 8-bit (or "chiptune") utilizes old-school computer game video sounds, and has been applied to a wide array of music from artists ranging from Daft Punk to the Smiths.

The 8-bit version of Reign in Blood was created by YouTube user Potatobombs1 (self-described as "a nerdy metal-head who has no life"), who has previously crafted 8-bit versions of other classic heavy metal albums from Iron Maiden (Number of the Beast), Metallica (Master of Puppets) and Megadeth (Countdown to Extinction), among others.