Dave Grohl, Gwen Stefani, 50 Cent, Alanis Morissette, Fergie, Miley Cyrus, Jennifer Aniston, Selena Gomez, Avril Lavigne, Gerard Butler, Sandra Bullock and Justin Theroux were among the celebrities to help Handler end her seven-year stint with the network known for Keeping Up With The Kardashians.

With the front row filled with actual singers, the all-star choir sang "Goodbye To E!," a parody of "We Are The World." "Thank you to my family and mom," exclaimed Handler as she closed the show. "I hope you're watching me! I'll see you on Netflix!"