The video features a decidedly retro feel, with Eminem joined by "Berzerk" producer, Rick Rubin, who mugs for the camera throughout the clip in front of a giant boom-box stereo. Rapper Kendrick Lamar pops up for a cameo appearance, as do members of hip-hop super-group Slaughterhouse, mostly notably fellow Detroiter and long-time Eminem associate, Royce da 5'9."

Shots of Eminem (sporting classic Detroit Pistons gear) are cut with random clips of people and old-school video shots of rocker Billy Squier performing his 1981 hit "The Stroke," which is sampled prominently throughout "Berzerk."

Detroit rock hero Kid Rock literally jumps into the clip for a quick appearance, with Eminem referencing Rock's 1999 smash, "Bawitdaba," in the new song's lyrics.